Life ScienceHeredityMS-LS3-1

DNA, Genes and Chromosomes

DNA carries the instructions for building an organism. A gene is a section of DNA with the instructions for one protein, and DNA is packed into chromosomes in the nucleus.

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In Membrane, Cytoplasm and Nucleus you saw that the nucleus is the cell's control center. What is inside it? Instructions, written in a molecule called DNA. This is where inherited traits come from.

Key idea

DNA carries the instructions for building and running an organism. A gene is a section of DNA with the instructions for one protein. DNA is packed into chromosomes in the nucleus. A chromosome is one long DNA molecule carrying many genes.
DNA is a double helix, like a twisted ladder. The rungs are pairs of bases: A with T, C with G.

Why it works

The order of the bases A, T, C and G spells out the instructions, the way the order of letters spells words. Because A always pairs with T and C with G, each side of the ladder can rebuild the other. That is how a cell copies its DNA before it divides, so nearly every cell of your body has a full set.
From big to small.
WordWhat it isSize
Chromosomeone long DNA molecule, coiled tightlylargest
Genea section of a chromosome with instructions for one proteinmiddle
Baseone "letter": A, T, C or Gsmallest

Worked example: How many?

Most human body cells have 46 chromosomes in 23 pairs. How many chromosomes does a skin cell have? A liver cell?
  1. Body cells are made by copying the DNA and dividing.
  2. Each copy gets the full set.

Answer: Both have 46. (Red blood cells are an exception: they lose their nucleus as they mature.)

Build the partner strand: A pairs with T, C pairs with G.

Common mistake

Students think genes and chromosomes are different things in different places, or that only some cells, like those in the blood, have DNA. A gene is part of a chromosome, the way a sentence is part of a book. And nearly every cell carries the whole book.

Practice

Pass with 3 right answers, the last 2 in a row. Each right answer earns 2 XP.

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Sources and further reading

  • Next Generation Science Standards, MS-LS3-1 (Heredity: Inheritance and Variation of Traits)
  • OpenStax, Concepts of Biology, 9.1 The Structure of DNA
  • National Human Genome Research Institute, Talking Glossary: Chromosome, Gene (genome.gov)
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